1. Chemical Sensors, Nanoparticles, and Microfluidics for Medical Diagnostics
A major research focus of the Wang group is the development of portable, wearable, implantable, and microfluidic chemical sensors for health monitoring and disease diagnosis outside of hospital settings. Current efforts include the design of ionophore-based ion-selective electrodes/optodes, fluorescent chemical sensing platforms in droplet microfluidics, and nanoparticles for sensing and imaging.
(Angew. Chem. 2019, 58, 8092; Anal. Chem. 2021, 93, 40, 13694)
2. Nitric Oxide-Releasing Nanocarriers and Bioimplants
Nitric oxide is a natural molecule with potent anti-thrombotic, bactericidal, anti-inflammatory, and pro-angiogenic properties. We are developing various nitric oxide release/generation strategies to reduce foreign body reactions and infections to biomedical implants like sensors, catheters, and cannulas. Of particular interest are 3D-printed patient-specific stents, urinary catheters, and insulin infusion cannulas that releases nitric oxide.